SINGAPORE — Stocks in Asia-Pacific were mixed on Wednesday as a recent rally bolstered by coronavirus vaccine hopes and reduced uncertainty in U.S. politics paused.
Mainland Chinese stocks led losses among the region's major markets: The Shanghai composite dropped 1.19% to close at approximately 3,362.33 while the Shenzhen component slipped 1.773% to about 13,656.09.
MSCI's broadest index of Asia-Pacific shares outside Japan dipped 0.37%.
Hong Kong-listed shares of Chinese smartphone maker Xiaomi fell 3.68%. The declines came despite the firm posting a roughly 19% year-over-year surge in its adjusted net profit for the three months ended Sept. 30.
"Our global smartphone shipments rose to the 3rd position in the third quarter of 2020, with an all-time high market share of 13.5%, according to Canalys," Xiaomi said in a statement.
The mixed moves in Asia came despite strong overnight gains on Wall Street.
The Dow Jones Industrial Average closed above 30,000 for the first time as it gained 454.97 points to 30,046.24. The S&P 500 also saw a record close, rising 1.6% to 3,635.41. The Nasdaq Composite added 1.3% to finish its trading day at 12,036.79.
Positive momentum in the race for a coronavirus vaccine has boosted global markets recently. Earlier this week, AstraZeneca announced that interim analysis showed its vaccine has an average efficacy of 70% in protecting against the virus.
The U.S. dollar index, which tracks the greenback against a basket of its peers, was at 91.96 after seeing levels above 92.4 earlier in the week.
The Japanese yen traded at 104.39 per dollar, having weakened from levels below 104 against the greenback this week. The Australian dollar was at $0.7353, following levels below $0.732 seen yesterday.
Oil prices were higher in the afternoon of Asia trading hours, with international benchmark Brent crude futures up 0.98% to $48.33 per barrel. U.S. crude futures also gained 0.78% to $45.26 per barrel.
Meanwhile, spot gold traded at $1,809.68 per ounce, following a recent slip from levels above $1,830 per ounce as risk sentiment improves.
Subscribe to CNBC PRO to access live PRO Talks, including our Dec. 2 discussion on opportunities and risks in international markets.