Asia-Pacific markets were largely lower as investors braced for further hikes ahead as Federal Reserve speakers reiterated more hikes are needed to tame inflation.
Minneapolis Fed President Neel Kashkari on Wednesday said the Fed will "continue doing what we're doing until we finish the jobs, and I'm committed to doing that." The U.S. 10-year Treasury yield briefly topped 4% overnight.
In Japan, the Nikkei 225 fell marginally to end at 27,498.87 and the Topix closed 0.16% lower at 1.994.57 . South Korea's Kospi climbed 0.62% to finish at 2,427.85, while the Kosdaq lost 0.56% to close 787.19.
Asia's Tesla suppliers were also closely watched as the company's stock fell more than 5% in after hour trade as Investor Day fell short on details about any new products or services.
Australia's S&P/ASX 200 rose marginally to end the day at 7,255.4. Hong Kong's Hang Seng index was 0.8% lower in its final hour of trade, while the Hang Seng Tech index fell 1.09%.
In mainland China, the Shenzhen Component lost 0.54% to finish at 11,849.5, while the Shanghai Composite was fractionally higher to end at 3,310.65.
Overnight, U.S. stocks were largely down as both the S&P 500 and Nasdaq Composite saw losses, while the Dow Jones Industrial Average ended the day just above the flatline.
— CNBC's Tanaya Macheel and Alex Harring contributed to this report.