A sign at the entrance to the Fort Sumter National Monument informs visitors it is closed because of the federal government shutdown October 2, 2013 in Charleston, South Carolina.

Cancellations and delays caused by the federal government shutdown spread across the United States on Wednesday, ruining dream vacations, upending carefully laid wedding plans and complicating the lives of millions of people.

From blood drives to daycare programs, musical performances to research projects, the disruptions caused by the political stalemate in Washington sparked growing frustrations and left people scrambling to make alternative plans.