Investors should not get too comfortable in the belief that Federal Reserve interest rate hikes are a long way off, said Esther George, hawkish president of the Kansas City Fed, which hosts the central bank's annual monetary summit in Jackson Hole, Wyoming.

"There's a lot of complacency right now, and if you look at the market path for interest rates relative, for example, to … the FOMC's projections, you will see that those have been far apart," George said in a "Squawk Box" interview aired Thursday, a day before Fed Chair Janet Yellen addresses the conference.