Lowe's missed earnings expectations on Wednesday but reported a 4.5 percent rise in quarterly sales as demand rose for products such as appliances and outdoor power equipment.

The shift toward bigger ticket items most likely accounted for slight weakness in gross margins, said Brian Nagel senior equity research analyst at Oppenheimer. Those high-priced items typically have lower margins, so while they boost revenues, they hurt profitability, he told CNBC's "Squawk Box."