Citi Group headquarters in New York.

U.S. equities are out of favor with global strategists at Citi, who have downgraded the asset class because of the potential impact of more Federal Reserve interest rate hikes and stalling corporate profitability.

Citi strategists led Robert Buckland highlighted the potential for weaker earnings per share (EPS) momentum in the U.S., in a note released on Tuesday. EPS is an important metric used by analysts and is used an indicator of a company's profitability.