Investors are increasingly betting against the shares of firearm producers with the rising prospect of gun control in the U.S., according to new data from financial data firm Markit, although the tragic Orlando shooting is expected to actually prompt traders to close their positions.

Short interest in North American gun maker Smith & Wesson has spiked 370 percent ahead since the first week of January, with 11.6 percent of the company's shares now out on loan, according to Markit data.