Democratic U.S. vice presidential nominee Senator Tim Kaine (L) shakes hands with Republican U.S. vice presidential nominee Governor Mike Pence at the start of their vice presidential debate at Longwood University in Farmville, Virginia, U.S., October 4, 2

As presidential election polling swings in Hillary Clinton's favor over Donald Trump, the rivals' lesser-known running mates will make the cases for their tickets Tuesday night.

The debate in Virginia will thrust Sen. Tim Kaine of Virginia and Indiana Gov. Mike Pence into a national spotlight recently hogged by Clinton and Trump, respectively. The vice presidential candidates will likely aim to take down each other's records and try to prop up their unpopular running mates.