KEY POINTS
  • Bristol Myers-Squibb is acquiring Celgene in a cash and stock deal valued at $74 billion.
  • Bristol Myers-Squibb's immuno-oncology drug Opdivo has struggled to keep up with Merck's Keytruda. 
  • Celgene has faced its own problems. Its stock has fallen more than 37 percent over the past year.
Tablets are pictured on the production line of Bristol Myers Squibb's pharmaceutical plant of French group UPSA in Agen, southwestern France.

Bristol-Myers Squibb is making a $74 billion bet — and investors aren't pleased.

The New York-based pharmaceutical giant on Thursday said it would acquire Celgene, a Summit, New Jersey-based cancer drug company, in a cash and stock deal valued at $74 billion. Under the agreement, Celgene shareholders will receive one Bristol-Myers Squibb share and $50 in cash for each Celgene share held, or $102.43 per share, a premium of 53.7 percent to Celgene's Wednesday close.