I had a lightbulb moment several years ago when I realized that good old-fashioned stock picking was the key to the tremendous investing success enjoyed by the likes of Buffett and Munger (married to very long-term ownership, capital reallocation, and very concentrated portfolios).  

It's not to say index investing doesn't work--my 401(k) is in plain vanilla S&P index funds like anyone else's--but that stock picking can generate returns far and above that. It's just really, really hard to do it well over time, so most people end up trailing the index (especially if they're paying someone else fees to try and do so).