When Liuba Grechen Shirley ran for New York's 2nd Congressional District in 2018, the Democratic mom of two had no clue about the barriers she would face on the campaign trail.

"There is no playbook for running for office with small children," Grechen Shirley, who had a 1-year-old and a 3-year-old at the time of her campaign, tells CNBC Make It. "It's a different experience. Donors don't take us seriously, voters often don't take us seriously and neither does the press. When you run with young children, the first question you're asked always is, 'Who will watch your kids while you're campaigning?'"