Home foreclosures are up, the market is down, unemployment is high, and consumer spending is flat. These days, nobody wants to buy a five-figure handbag—or do they?

In the middle of the financial malaise, one of the accessories market's most expensive sectors—exotic handbags—are actually on the rise, say some in the retail industry. Satchels made from rare and pricey crocodile, python, and lizard skins—with price tags in line with everything from a monthly mortgage payment to the price of a small car—have been selling well over the last 12 months, even in recent tumultuous weeks.