Mortgage applications were hurt by a 13 percent drop in FHA applications, a direct result of a Trump administration move.
The affirmation to clear Mnuchin and Price came after Democrats boycotted the vote for a second day.
The overall economy grew for the 92nd consecutive month, The Institute for Supply Management said.
Trump's pick sets the stage for the second straight year of partisan clashes over the court.
China's official January manufacturing PMI indicated continued expansion, as the mainland economy shows signs of stabilizing.
Asian shares were mostly higher on Wednesday after China's manufacturing sector showed signs of expansion in January.
Check out which stocks posted moves after the bell on Tuesday.
"Repatriation is front and center. That is good for the country and Apple," Apple CEO Tim Cook told CNBC.
Apple has returned to growth, but its future is less certain than analysts thought.
U.S. equities traded mixed as investors continued to evaluate the latest policies from the White House.
A Reuters survey pointed to a strong start by the exporter group in implementing its first supply cut deal in eight years.
Spicer is expected to address Trump's Supreme Court pick and immigration executive order.
Kelly has faced a tough task in enforcing an order that he reportedly knew little about before it was signed.
Economists expected the Consumer Confidence Index to hit 113 in January, according to Thomson Reuters.
MasterCard reported fourth-quarter earnings that topped analysts' expectations by a penny a share on Tuesday.
Germany is using a "grossly undervalued" euro to gain advantage over the United States and its own European Union partners, Donald Trump's top trade adviser told the Financial Times.
Shares of UPS were on pace for their worst day since January 2015.
Euro zone officials received a slew of good news on Tuesday morning with stronger-than-expected growth and inflation figures and a falling unemployment rate.
The U.S. is moving to implement travel restrictions on seven Muslim-majority countries that were opposed by acting attorney general.
The German lender Deutsche Bank has received a new $204 million bill for inadequate anti-money laundering controls.