With Apple's (AAPL) disappointing announcement, the NASDAQ was set to open heavily toward the downside. On the openeing bell, the Nasdaq opened down ~65 points or almost 3%.
The last time the NASDAQ opened down over 60 points was on Sept 21, 2001 after the 9/11 attacks. The NASDAQ opened down 75 points or 5% that day. The largest drop on the open was one year earlier when the NASDAQ dropped 212 points on the open.