AB InBev plans to cut more than 300 staff members in Belgium and Germany, where it employs 2,700 and 3,000 people respectively. Jobs will also be shed in France, Luxembourg, the Netherlands and Britain.
The company said the cuts are necessary because beer consumption has fallen 20 percent in Belgium since 2000, according to the Telegraph.
Angered by the job losses, union members took 10 managers hostage at the group's Jupille brewery in eastern Belgium last Thursday, but the executives were released unharmed the following day, according to the newspaper.
Employees have been protesting outside plants in Leuven – where Stella Artois is brewed – as well as factories in Hoegaarden and Jupille for the last week.
Despite winning a court ruling to end the blockade in Leuven on Friday, the company is not seeking to enforce the order for now, Reuters said.
It does reportedly have the legal right to break the blockades by force but wants to avoid that for now.
A union official said a move would trigger a strike by all Anheuser-Busch InBev's workers in Belgium.
Staff can go into the breweries but the blockades at the gates mean production has all but ground to a halt because of the difficulty in getting supplies in.
AB InBev was created in 2008 when InBev bought the Budweiser maker to become the world's biggest brewery. Since then the company has been cutting costs to reduce its debts.