White House Chief of Staff Rahm Emanuel will depart his post to run for mayor of Chicago, and NBC News reports that he will be replaced by Senior Adviser Pete Rouse.
President Obama is to make an announcement at a White House East Room event on Friday. White House spokesman Robert Gibbs would not confirm Emanuel is the subject of the announcement but the sources told Reuters Emanuel's announcement would come on Friday.
Rouse was previously President Obama's chief of staff during his tenure in the U.S. Senate. He was part of a team of advisers that guided then-Senator Obama towards a run for president, according to a biography page on Change.gov.
"Pete has been with Senator-elect, Senator, President-elect and now President Obama," Gibbs told reporters. "There is a complete loyalty and trust with somebody like Pete."
The Wall Street Journal earlier reported Emanuel would resign Thursday.
Emanuel, a former congressman from Chicago, has been the source of widespread speculation ever since Chicago Mayor Richard Daley announced this month he would not seek re-election.
In an April television interview, Emanuel had called it "no secret" he'd like to run for mayor.
Daley, who has held the mayor's job since 1989 and carried on a family dynasty, surprised many with his announcement. The choice for Emanuel suddenly became whether he would make a dash for the political job he has openly coveted, at a cost of uprooting his family again and quitting his post of national influence sooner than he thought.