Sales for the most recent quarter rose to $7.6 billion, up from $6.86 billion last year.
The company was seen earning 99 cents a share on revenue of $7.35 billion, according to a consensus estimate from Thomson Reuters.
Shares of AmEx gained in extended trading Wednesday. Get real-time quotes for American Express here.
The stock closed at $52.10 in the regular New York Stock Exchange session. Volume exceeded 6.5 million shares before the closing bell.
Earlier, a federal court judge approved a settlement between the Justice Department and MasterCard and Visa that requires the card processing networks to allow retailers to offer discounts or rebates to customers for using a particular kind of card.
However, AmEx refused to settle, vowing to wage a multiyear fight on the grounds that the deal would promote steering customers from one payment network to another without enhancing competition.
In the meantime, AmEx introduced a new digital payment and commerce platform in March called Serve, which offers person-to-person, online, mobile and traditional card capabilities in a single account.