Another blast of winter weather in the U.S. Southeast and Midwest has forced the cancellation of thousands of flights Tuesday.
As of noon EST, more than 3,000 flights had been canceled and 4,500 had been delayed, according to flightaware.com.
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Most of the disruptions were at Atlanta Hartsfield from snow, Houston Intercontinental from freezing rain and Chicago O'Hare from extremely cold temperatures.
(Read more: Once-in-a-generation storm descends on Deep South)
The Louis Armstrong New Orleans International Airport tweeted that all Southwest and JetBlue flights were canceled there.
The weather, of course, has ripple effects even to sunny locations. Fort Lauderdale, for example, said 27 flights had been canceled.
In addition to the airlines, Amtrak said it would be operating its trains Tuesday on modified schedules for its Chicago Hub Services.
MegaBus also said it had a number of cancellations through Wednesday, affecting routes in Alabama, Wisconsin, Minnesota, Nebraska, Michigan, Ohio, Illinois, Indiana, Kentucky, Tennessee, Virginia, Pennsylvania, Texas, Mississippi and Louisiana.
Forecasters were predicting snow and ice from Texas to Virginia by mid-week as precipitation moving in from the south met with cold air already chilling the region. Meanwhile, in the Midwest, plummeting temperatures and increasing winds took root for another day even as the storm moved south.
Several states in the central U.S. saw schools and other facilities close for a second consecutive day as dangerous wind chills were predicted. In Minnesota, forecasters said wind chills could reach 35 to 50 degrees below zero.
Airlines are expecting improvement at the Southeastern airports Wednesday, but problems may persist in the Midwest, according to flightaware.com.
(Read more: Airport upgrades: Changing rooms, outdoor plazas)
—By CNBC.com. The Associated Press contributed to this story.