Langone — who switched his support to Kasich after New Jersey Gov. Chris Christie dropped out of the race — said on "Squawk Box" that the Trump phenomenon has little to do with the candidate.
"Something is radically wrong [with the nation] and this is what's happened," Langone said. "It's got nothing to do with Trump. It's got everything to do with the American people, saying, 'Wait a minute. Bring me to the party. What about me? Let me have a future. Let my kids have a future.'"
Refraining from outright criticizing Christie's endorsement of Trump last week, Langone said, "I don't know whether [Christie] is right or wrong." But he added: "I know he didn't call me to ask me what I thought. My fingerprints aren't on that one."
Druckenmiller was far less polite. "It's disgraceful what [Christie] said about Donald Trump, to come out and endorse the man so he can be attorney general. I just find it appalling." Christie had served as U.S. attorney for the District of New Jersey for six years before being elected governor. It's been rumored that Christie endorsed Trump as part of a deal to get a position including attorney general.
Meanwhile, a joint editorial from six New Jersey newspapers is calling for Christie to resign or for voters to "initiate a recall effort," after the Trump endorsement.
"With Ken, I tried to get [Christie] to run in 2012," said Druckenmiller. "I got to know him well about a year ago. [But] it became clear to me about six to nine months ago that the man believed in absolutely nothing but his own ambition. If I had any doubts, he more than proved it last week," when he endorsed Trump.
Trump won seven of the 11 Super Tuesday contests, with key victories in the North as well as the South. He steamrolled his rivals in Massachusetts and Vermont, while notching fairly decisive wins in Virginia, Georgia and Alabama.
Taking stock in the voting thus far in the nominating contests, Langone said that one thing's for sure, "We've proven that America is not interested in dynasties."
Jeb Bush, former Florida governor, started the 2016 campaign with a huge fundraising lead and the early moniker of presumptive Republican nominee.
"He spent $36 million in New Hampshire, 19,000 TV ads in New Hampshire and didn't do very good," Langone said.
"This notion that money buys elections, Bernie Sanders, forget it," Langone said, firing a shot at the Democratic front-runner and dynasty candidate Hillary Clinton.
Clinton, like Trump, won seven out of the 11 primaries and caucuses on Super Tuesday. But challenger Sanders won four contests, including his home state of Vermont.