Grover Norquist: Clinton already lost the election

Republican party on the brink?
Republican Party on the brink?   

Democratic front-runner Hillary Clinton lost her chances of becoming president after alienating two key states, anti-tax crusader Grover Norquist said Monday.

"Under her new rules, fracking would exist almost nowhere," the president and founder of Americans for Tax Reform told CNBC's "Squawk on the Street." "Democrats used to be able to insult the energy industry because they lived in Texas, Oklahoma, Louisiana and Alaska [and] they don't vote Democrat. But she declared war on Pennsylvania and Ohio with that statement. That's not the way to win the election."

Clinton said in a debate Sunday in Flint, Michigan, she does not support fracking.

The Marcellus shale formation stretches underground across Pennsylvania and into several other states. The advent of hydraulic fracking set off a natural gas boom starting in 2008 in those states.

Read More16 questions for Hillary Clinton

Norquist also said Clinton took herself out of contention with her comment on guns, alienating a "bloc of the electorate that didn't exist 20 years ago."

In the debate against Sen. Bernie Sanders, she said: "I think we have to try everything that works to try to limit the numbers of people and the kinds of people who are given access to firearms."

Said Norquist: "Hillary Clinton is old enough that she doesn't know that, since she got involved in politics, 13 million Americans have active concealed weapon permits, 5 percent of the adult population. She announced it was her policy to reduce the number of people who have guns, not bad people; she said 'people' who have guns."

Norquist has not made an endorsement, but said he is confident that the GOP can unite one behind one candidate when the general election comes.

"Hillary Clinton is a uniter, not a divider."

—Reuters contributed to this report.

Read MoreHillary: I'm against bad behavior, not business