U.S. stock index futures pointed to a lower open on Friday as traders eyed the release of September manufacturing activity and comments from Fed speakers.
Friday will see the September flash manufacturing PMI released at 9:45 a.m. ET.
Philadelphia Fed President Patrick Harker, Atlanta Fed President Dennis Lockhart and Cleveland Fed President Loretta Mester are scheduled to speak at noon in Philadelphia on a panel about the Fed's role in communities.
Dallas Fed Robert Kaplan is set to speak at 12:30 p.m. ET at the Texas Oil & Gas Association Lone Star Energy Forum.
In oil markets, Brent crude traded at $47.86 a barrel on Friday, up 0.44 percent, while U.S. crude held at $46.27 a barrel, down 0.11 percent.
In Europe, the pan-European Stoxx-600 index was 0.65 percent lower on Friday. In Asia, Japan's Nikkei closed 0.83 percent lower. In China, the Shanghai Composite closed 0.28 percent lower.
CNBC's Patti Domm contributed to this report