U.S. stock index futures pointed to a mixed open on Wednesday following a rally on better-than-expected economic data in the previous session.
On the earnings front, Paychex and UniFirst are scheduled to report before the bell. Lululemon Athletica and Worthington Industries are both due to report after the market close.
Wednesday also will see pending home sales for February released at around 10 a.m ET.
In Europe, the pan-European Stoxx-600 index was around 0.08 percent lower on Wednesday, after UK Prime Minister Theresa May formally began the Brexit process.
In Asia, the Shanghai Composite in China closed 0.36 percent lower, while the Nikkei in Japan closed 0.08 percent higher.
In oil markets, Brent crude traded at around $51.64 a barrel on Wednesday, up 0.6 percent, while U.S. crude was around $48.61 a barrel, up 0.5 percent.
Oil prices extended gains from the previous session as investors expectations lifted that OPEC-led production cuts could continue into the second half of 2017.