* DuPont's earnings forecast, job cuts weigh on oil
* Keystone pipeline restart Monday helps pressure oil
* Brent tests support at 100-day moving average
* U.S. crude stocks likely rose last week - analyst poll
* Coming Up: API oil data 4:30 p.m. EDT Tuesday
(Updates prices, market activity)
NEW YORK, Oct 23 (Reuters) - Oil fell sharply on Tuesday as concerns about slowing global economic growth, Europe's ongoing debt crisis and weak outlooks from corporations reporting earnings pressured oil and equities markets.
Brent fell a sixth straight session and U.S. crude pulled back a fourth consecutive day as economic concerns and an improving crude oil supply picture continued to counter any potential lift from Middle East turmoil and Iran's dispute with Israel and the West over Tehran's nuclear program.
Chemical company DuPont cuts its earnings forecast and announced 1,500 job cuts in its third-quarter earnings report that missed Wall Street expectations, helping push equities, oil and other commodities lower.
The Thomson Reuters-Jefferies CRB index, a gauge widely followed by commodity investors, fell 1.4 percent.
DuPont's gloomy outlook came a day after heavy machinery maker Caterpillar Inc warned the economy was slowing faster than expected.
Spain's borrowing costs rose after ratings agency Moody's downgraded five of the country's regions.
Business morale in France's manufacturing sector slumped in October to its lowest level in over two years as export demand from the euro zone weakened, adding to concerns about sputtering economic growth.
TransCanada Corp's Monday restart of its Keystone pipeline carrying crude oil from Canada to the United States added pressure on oil futures.
Brent December crude fell $1.81 to $107.63 a barrel by 12:52 p.m. EDT (1652 GMT).
Brent dipped to the lowest level since Sept. 20 in afternoon activity, touching $107.35 and testing the 100-day moving average.
U.S. December crude was down $2.55 at $86.10 a barrel, having fallen to $85.69, the lowest since mid-July.
``The main bearish driver is the state of the economy,'' said Filip Petersson, an analyst at SEB in Stockholm. ``And that's taken all markets down quite a bit.''
U.S. November heating oil slumped more than 1 percent. It was down 5.01 cents at $3.0266 a gallon, having fallen during the session to $3.0193, below the 200-day moving average of $3.0278.
U.S. November RBOB gasoline retreated 2 percent and Tuesday's low trade of $2.5690 a gallon was the weakest for gasoline since June.
Oil prices also felt pressure from expectations that U.S. oil inventories likely rose last week as imports recovered, a preliminary Reuters poll of analysts showed.
Crude inventories were expected to have risen 1.7 million barrels for the week ended Oct. 19.
The American Petroleum Institute will release its inventory report at 4:30 p.m. EDT (2030 GMT). The U.S. Energy Information Administration (EIA) will issue the government's report on Wednesday at 10:30 a.m. EDT (1430 GMT).
SUPPLY THREATS
The slide in crude prices on Tuesday came even as the potential remains for Middle East turmoil to cause a disruption to the region's oil supply.
Iran said on Tuesday it would stop oil exports if pressure from Western sanctions got any tighter and that it had a ``Plan B'' contingency strategy to survive without oil revenues.
Major powers may ask Iran for stricter limits on its nuclear work if it wants an easing of harsh sanctions - a long-shot approach aimed at yielding a negotiated solution, according to Western diplomats.
Syrian rebel were attempting to seize an army base close to the main north-south highway. Rebels say capturing the base would help create a ``safe zone'' allowing them to focus on President Bashar al-Assad's southern strongholds.
Fears that Syria's conflict could envelope its neighbors and affect the key infrastructure and production in the region have been supportive to oil prices.
(Additional reporting by Peg Mackey in London and Manash Goswami in Singapore; Editing by Marguerita Choy and Alden Bentley)