It's been a great ride but with shares up a whopping 127% since the beginning of the year, Cramer thinks it's time to head for the exits.
"Rite Aid has been absolutely jamming – this is the kind of gain you can get when a company turns itself around," exclaimed the Mad Money host.
As a percentage gain the move is spectacular but looking at the actual share price, the gain is almost pocket change.
Rite Aid was trading at just $1 dollar a share and now it's around $3.15. Wouldn't it stand to reason that the stock has more upside with institutional investors potentially entering if it can break above $5?
Cramer doesn't think that's a bet worth making; at least not in a big way.
"The first rule of investing is that when you have a monster gain, lock in profits," Cramer said. That's only sensible.
But the Mad Money host's skepticism involves much more than simple profit taking.