Thousands of protesters took to the streets in cities across Egypt on Friday, including Tanta, Alexandria and Nasr City in eastern Cairo.
Ahead of the planned protests, the Egyptian army sealed off all access roads to Tahrir Square and surrounding areas before a planned mass protest following Friday prayers, according to state TV.
The interior ministry said live ammunition would be used against any protesters approaching government buildings. It also said no sit-ins were allowed anywhere.
Barbed wire and fences were set up in the central Cairo square that has become a focal point for protests after the Muslim Brotherhood called for a "day of anger" in protest against the ousting of Mohammed Morsi as president and the military crackdown that has subsequently gripped the country.
Over 600 people have been killed during the violent clashes between the military and supporters of Morsi belonging to the Muslim Brotherhood, according to the Egyptian ministry of health, although higher figures are being reported.
The consensus is that the death toll will rise further on Friday after the Brotherhood called for a nationwide march of millions following Friday prayers to show their anger at the crackdown.
(Read more: Scenes from the turmoil in Egypt)
"After the blows and arrests and killings that we are facing, emotions are too high to be guided by anyone," Brotherhood spokesman Gehad El-Haddad said. "Despite the pain and sorrow over the loss of our martyrs, the latest coup makers' crime has increased our determination to end them," a statement from the party said.