Americans can't expect the government to police the world and provide an "endless welfare state," Paul said. Unless some major change happens, he added, the government will remain in a stalemate.
(Related: Obama to CEOs: Washington 'locked up' in a stalemate)
When asked whether he would have supported Sen. Ted Cruz (R-TX) in an effort to defund Affordable Care Act, often referred to as Obamacare, Paul said, "Yes, I would think that you would have to what is necessary. If you continue the process, it just makes things worse. It delays the inevitable. … if we don't do it, the consequences will be so much greater."
(Read more: House Republicans plan to defund Obamacare)
However, he said, Congress is unlikely to follow through and will use "scare tactics" to make the public to believe this level of spending is necessary.
Paul has also been a vocal critic of the Federal Reserve, which he believes should be abolished. Regarding the potential group of nominees for Fed chairman, Paul said "I'd pick none of the above, because I don't think it makes any difference. The all endorse the principle of manipulating interest rates and believing that they can decide how much money supply there should be."
(Read more: End the Fed, save the Dollar: Ron Paul)
"One individual might manage things slightly differently, but overall it would be the same thing. It's still the monetary system that we have to deal with, not the particular manager," he said. "A few individuals and one in particular behind the scenes in secret pretending they know what interest rates should be … it's positively amazing that the economy tolerates it."
Paul said gold, which he acknowledged is a part of his personal portfolio, should be a long-term investment and an insurance policy against government actions. "We do know that governments will continue to spend, the deficit problem hasn't been solved. … The employment statistics are not quite as rosy as some people believe," he added.
"We're in big trouble. ... There is a lot of inflation, a lot of unemployment. To say that gold went down in the last year, that doesn't tell you a whole lot. You've got to look more long term and you have to look at the basics," he said. "I think most people who study free market economics know that this is very, very fragile. The dollar is fragile. I think people should be more cautious than overly confident."