U.S. stock futures pointed to a lower open on Wall Street on Tuesday, with Greece jitters expected to weigh on sentiment ahead of the start of two-day Federal Reserve meeting.
The U.S. central bank is not expected to announce any changes to its monetary policy this week, but talk that the Fed could lift interest rates in September for the first time since 2006 is growing amid improving economic conditions. And that means the Fed's post-meeting statement on Wednesday is likely to be scrutinized closely.
Read More Greece weighs while traders await Fed
Greece is also expected to remain in the spotlight on Tuesday, with the country's Prime Minister Alexis Tsipras on Monday blaming creditors for the collapse of talks on unlocking aid for reforms at the weekend.
The impasse has raised concerns that Athens is heading for a debt default that could end with it leaving the euro zone.
Greek jitters continued to undermine global markets, with European stocks trading lower on Tuesday and Asian shares closing broadly in the red.
Euro zone finance ministers are next due to discuss the Greek crisis on Thursday – when Tsipras has a planned visit to Russia.
Read More Greece defiant, accused of 'breaking all the rules'
"With reports already circulating of plans by EU creditors to impose capital controls in the event Greece rejects a take it or leave it deal set to be put forward on Thursday, it would appear that the clock is ticking ever so closer to midnight," Michael Hewson, chief market analyst at CMC Markets, said in a note.
"Or to take the analogy that little bit further we are now at DEFCON 1 with respect to the seriousness of the current situation, and a potential default."
U.S. stock market futures were broadly lower in London trade, with Dow Jones Industrial Average futures trading 50 points lower.
Wall Street shares closed lower on Monday as concerns about Greece's future took a toll.
May housing starts data at 08:30 a.m. ET will also be eyed as the Fed kicks off its meeting. The data follow Monday's National Association of Home Builders sentiment survey, which showed confidence rising to its highest level in nine months.
Earnings due this session include FactSet Research, Adobe Systems, Bob Evans Farms and La-Z-Boy.