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  • Isis trading halts as FDA reviews key drug's risks Thursday, 18 Oct 2012 | 12:58 AM ET

    Drug developer Isis Pharmaceuticals Inc. and partner Genzyme said Thursday a panel of advisers to the Food and Drug Administration had voted 9 to 6 to recommend approval of Kynamro, for treating patients genetically predisposed to have sky-high LDL, or bad cholesterol. The FDA is not bound to follow recommendations of its advisers, but usually does so.

  • Tracing odds on next TV show to get the ax Thursday, 18 Oct 2012 | 12:57 AM ET

    NEW YORK-- Watch out, Fox. Less than four weeks into the new season, CBS' "Made in Jersey" is already swimming with the fishes, and NBC announced on Thursday that the comedy "Animal Practice" will be out the door next month. Site founder Bill Gorman, asked to go out on a limb, predicted "The Mob Doctor" on Fox would be the next to disappear _ but NBC beat him to the punch.

  • Shoe Carnival CEO retiring, exec replacing him Thursday, 18 Oct 2012 | 12:52 AM ET

    EVANSVILLE, Ind.-- Citing health reasons, Shoe Carnival CEO and President Mark Lemond is retiring from the footwear and accessories company after 16 years leading it. The company's executive vice president and CFO, W. Kerry Jackson, will in addition become its chief operating officer, Shoe Carnival Inc. said Thursday. Shoe Carnival has 347 stores in 32 states.

  • Marriott Vacations posts 3Q net income, revenue up Thursday, 18 Oct 2012 | 12:51 AM ET

    ORLANDO, Fla.-- Timeshare company Marriott Vacations Worldwide Corp. reported a slim profit on higher revenue in the third quarter and raised its forecast for the year on strength in its North American operations.

  • GM wins dismissal of lawsuit over Einstein image Thursday, 18 Oct 2012 | 12:43 AM ET

    DETROIT-- A federal judge in California has dismissed a lawsuit challenging the use of Albert Einstein's image in a magazine ad by General Motors. The Detroit News says the Hebrew University of Jerusalem filed the lawsuit against GM. Information from: The Detroit News, http://detnews.com/.

  • Romney ad advantage doesn't tell the whole story Thursday, 18 Oct 2012 | 12:42 AM ET

    An Associated Press analysis of presidential campaign advertising data from April through last week found that pro-Romney spending has exceeded pro-Obama ad spending by at least $65 million across the nine states expected to decide the election: Colorado, Florida, Nevada, New Hampshire, North Carolina, Ohio, Virginia, Iowa and Wisconsin.

  • SAfrica miners reject Zuma's plea to end strike Thursday, 18 Oct 2012 | 12:39 AM ET

    FOCHVILLE, South Africa-- Ernest Morake shook his head and laughed when he heard that South Africa's president wanted striking miners to return to work. In a speech on the state of the economy on Wednesday, Zuma said wildcat strikes were damaging South Africa's economy and asked striking miners to immediately return to work.

  • BioTime makes offer for Geron stem cell assets Thursday, 18 Oct 2012 | 12:36 AM ET

    In a letter to Geron shareholders, BioTime suggests two deals that would form a new publicly traded company owning Geron's stem cell assets with some of BioTime's. It said Geron could have a stake of up to 45 percent in the company, which would also hold $40 million in BioTime stock along with shares of some BioTime stem cell subsidiaries.

  • News Summary: MGM China lands $2.5B Macau casino Thursday, 18 Oct 2012 | 12:34 AM ET

    FEELING LUCKY: The Chinese arm of MGM Resorts International signed a deal for a new $2.5 billion casino resort in Macau, the world's biggest gambling market. IN THE CHIPS: The company plans to build a casino resort that will include a five-star 1,600- room hotel, 500 gambling tables and 2,500 slot machines, MGM China said in a statement.

  • Stolen art can be burden without connections Thursday, 18 Oct 2012 | 12:34 AM ET

    PARIS-- The burglars dashed out the back door with seven masterworks, then sped on screeching tires into the night. If the thieves who robbed Rotterdam's Kunsthal exhibition this week don't have a plan, the stolen art could quickly become a burden.

  • *Akin rape remark highlighted in talking brochures Thursday, 18 Oct 2012 | 12:32 AM ET
  • Jason Aldean makes surprise announcement in Boston Thursday, 18 Oct 2012 | 12:29 AM ET

    BOSTON-- Jason Aldean will be making history at one of baseball's most historic sites. Aldean will be the first country music star to play a concert at Fenway Park, the iconic home of the Boston Red Sox.

  • Utility to help preserve open space in Connecticut Thursday, 18 Oct 2012 | 12:27 AM ET

    ENFIELD, Conn.-- Northeast Utilities says it is setting aside nearly 1,000 acres in a land trust to help preserve open space in Connecticut. The Hartford- based parent company of Connecticut Light& Power announced Thursday that the land trust will include 723 acres in Sharon, 188 acres on the Connecticut River in Enfield, 57 acres in Newtown and 13 acres in Waterford.

  • British lawmakers in new clash over expenses Thursday, 18 Oct 2012 | 12:25 AM ET

    LONDON-- Campaigners say British lawmakers are headed for another clash over their expenses _ three years after six legislators were jailed amid revelations that politicians had billed the public for items including an ornamental duck house and pornographic movies.

  • 27 people displaced as fire claims small ND town Thursday, 18 Oct 2012 | 12:25 AM ET

    BUCYRUS, N.D.-- A tiny southwestern North Dakota town has been all but destroyed by a wind-fueled wildfire that displaced its 27 residents, prompting an outpouring of assistance from surrounding communities, officials said Thursday. The chairman of the County Commission said the fire razed four homes in the town about 60 miles south of Dickinson.

  • News Summary: Syria airstrikes kill at least 43 Thursday, 18 Oct 2012 | 12:24 AM ET

    GOVERNMENT ATTACKS: Government airstrikes on rebel areas in northern Syria killed at least 43 people and leveled buildings, forcing residents to search through rubble for bodies, anti-regime activists said. And this week, Human Rights Watch accused Syria of using cluster munitions.

  • AutoZone names PepsiCo exec to its board Thursday, 18 Oct 2012 | 12:20 AM ET

    MEMPHIS, Tenn.-- AutoZone Inc. said Thursday that it elected PepsiCo executive Enderson Guimaraes to its board. In addition, AutoZone said two of its current board members, William Crowley and Robert Grusky, will not stand for re-election at the company's annual shareholder meeting in December. AutoZone's stock rose $2.08 to $371.55 in midday trading.

  • *Analysts lower CSX targets on weak coal demand Thursday, 18 Oct 2012 | 12:17 AM ET
  • Dollar rises after mixed US economic data Thursday, 18 Oct 2012 | 12:15 AM ET

    That's a sign layoffs are increasing, but the Labor Department said that there were technical reasons behind rise, such as delayed figures from California. The Federal Reserve Bank of Philadelphia says that manufacturing in the Philadelphia region expanded in October after five months of declines.

  • Alliance Data Systems 3Q profit jumps 27 percent Thursday, 18 Oct 2012 | 12:13 AM ET

    DALLAS-- Alliance Data Systems Corp., which manages loyalty and rewards programs for retailers and others, posted a 27 percent increase in third-quarter earnings, led by growth in its private label business. Alliance said Thursday it earned $119.5 million, or $1.84 per share, in the three months that ended Sept. 30.