The S&P 500 and Nasdaq Composite started the new quarter with solid gains on Wednesday, with market sentiment getting a lift from positive coronavirus vaccine news and strong U.S. economic data. 

The S&P 500 closed 0.5% higher at 3,115.86. The tech-heavy Nasdaq Composite posted a record closing high, rising 0.95% to 10,154.63. The Nasdaq-100 index — which is made up of the composite's 100-largest nonfinancial stocks —jumped more than 1% to an all-time high and closed at 10,279.25. The Dow Jones Industrial Average lagged, falling 77.91 points, or 0.3%, to 25,734.97.