Pichai spoke before a group of more than 1,000 entrepreneurs, investors and government officials at the 2016 Global Entrepreneurship Summit in Palo Alto, California.
For the long-time engineer, it's no surprise Pichai chose a quote by Thomas Edison, the American inventor who brought the world the light bulb and the first way of recording sound.
That quote by Edison is: "I have not failed, I've just found 10,000 ways that don't work. "
The summit took place in Silicon Valley, which Pichai described as "more of an idea than a location," since innovation isn't limited to the region and is happening around the around.
Pichai said that entrepreneurship is "about more than buildings apps to make money. It's about transforming industries, creating millions of jobs, curing diseases and fighting global warming."
The Google CEO's advice to innovators?
"Never give up and keep building," Pichai said.