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U.S. stock futures pointed to a mixed open Friday, in an investor sentiment tug-of-war between more encouraging Covid vaccine news and skyrocketing infections. The Dow Jones Industrial Average, as of Thursday's close, was up more than 11% in November. (CNBC)

Pfizer (PFE) and BioNTech (BNTX) said they'll apply with the FDA on Friday for emergency use authorization for their vaccine, the first to go through the regulatory process. At the same time, the U.S. on Thursday recorded coronavirus cases of 187,883, by far the nation's single-worst day during the pandemic.