When it comes to investment opportunities in the current climate, the United States still beats them all, OptionMonster's Pete Najarian said Wednesday.

"When you really look across at what's working right now, I think you want to look at the best house, and the best house right now by far is the United States," he said.

On CNBC's "Fast Money," Najarian said that U.S.-based stocks related to the production of shale oil and financials were doing well, noting heavy activity in Wells Fargo was one example.

"That's as U.S. as it gets," he said.

(Read more: 'Pockets of opportunity' in Europe: Gemma Godfrey)

Airlines, too, were seeing an "absolute scorching move to the upside," as shares of Delta Air Lines, United and JetBlue have moved higher, Najarian said. "So, it's an all-American sort of a lovefest right now, and I certainly look at the United States as the best house."

Stephen Weiss of Short Hills Capital agreed.

"For all the talk about European stocks, European markets being undervalued relative to the U.S., I don't believe it's true because they've got many more financials that dilute the valuation, bringing the P/E lower," he said.

(Read more: 5-star fund manager's top small-cap stocks)

Weiss added that Europe's economy would continue to exhibit more "stop-and-go" than the U.S., which appears to have strength ahead of it.

Corporate earnings, Weiss added, were still "spring-loaded," which were ready to climb "if you get a slight pick-up in the economy to make the market look cheap again."

— By CNBC's Bruno J. Navarro. Follow him on Twitter @Bruno_J_Navarro.

— CNBC's Katie Young contributed research to this report. Follow her on Twitter: @katiecnbc.

Trader disclosure: On Sept. 25, 2013, the following stocks and commodities mentioned or intended to be mentioned on CNBC's "Fast Money" were owned by the "Fast Money" traders: Stephen Weiss is long C; Stephen Weiss is long BAC; Stephen Weiss is short JCP; Jon Najarian is long AAPL; Jon Najarian is long JPM; Jon Najarian is long FB; Jon Najarian is long MSFT; Jon Najarian is long MAKO; Jon Najarian is long BIOS; Jon Najarian is long DRYS; Jon Najarian is long BX; Jon Najarian is long NS; Jon Najarian is long NFX; Jon Najarian is long NAT; Michael Murphy is long BAC; Michael Murphy is long C; Michael Murphy is long JPM; Michael Murphy is long JCP; Pete Najarian is long AAPL; Pete Najarian is long calls C; Pete Najarian is long calls WFC; Pete Najarian is long calls INTC; Pete Najarian is long calls YHOO; Pete Najarian is long FB; Pete Najarian is long SBUX; Pete Najarian is long calls MSFT; Pete Najarian is long BX; Pete Najarian is long calls NS.