Lots of hotels have so-called presidential suites, but very few of them are valued at $20 million.

The 6,000-square-foot presidential penthouse suite at the Fairmont in San Francisco is in a league of its own, in size and VIP history.

The suite is truly "presidential." Back in 1945, President Harry Truman, along with other world leaders, met there in preparation of drafting the charter that created the United Nations.

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The penthouse unfolds on the entire eighth floor of the historic main building of the hotel and includes three large bedroom suites, a formal dining room, a billiard room with hand-carved wood walls, a grand piano, a private, two-story circular library with a ceiling painted in gold leaf and a terrace with jaw-dropping views of the San Francisco skyline.

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Guests who stay at the penthouse have an army of staff at their beck-and-call, including a world-class chef, around-the-clock butler service, a team of housekeepers, a massage therapist, personal trainer and 200,000 honey bees.

The bees reside in the Fairmont Hotel's very own beehive. They produce "suite" honey for the hotel's VIP guests.

An overnight stay in this mega-hotel room runs $15,000 for a single night.

—By CNBC's Erin Barry and Ray Parisi.

To see some secrets hidden within the penthouse, tune into CNBC's Secret Lives of the Super Rich at 9 p.m. ET/PT Wednesday Feb 5.

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