President Donald Trump said on Monday that China is ready to come back to the negotiating table and the two countries will start talking very seriously.Politicsread more
The escalating trade war between Washington and Beijing dominated discussions at the G-7 gathering in France.Politicsread more
The latest round of tariff announcements in the last few days means that by the end of the year, essentially all Chinese goods exported to the U.S. will be subject to duties.China Economyread more
Futures fell after Trump said the U.S. will raise tariffs on more than $500 billion worth of Chinese imports, increasing trade tensions.Marketsread more
As Washington and Beijing continue to up the ante in their protracted trade fight, the potential of a recession in the U.S. is now "the biggest concern," according to Standard...US Economyread more
Tensions stemming from the U.S.-China trade war escalated sharply over the last few days, with much happening as Asian markets were shut down for the weekend.China Economyread more
Clouding the G-7 gathering, which represents the world's major industrial economies, are the tit-for-tat tariffs between Washington and Beijing.Politicsread more
Neither the U.S. nor China wants to be seen as the party that derailed trade talks, says William Reinsch of Center for Strategic and International Studies.World Economyread more
China said Friday it will be resuming 25% duties on U.S. autos, and a further 5% on auto parts and components.Asia Marketsread more
World leaders, environmental groups and celebrities have publicly decried the vast swaths of forest being destroyed by the fires.World Newsread more
Education Minister Ong Ye Kung says the Singapore government has been preparing for the challenge of an aging workforce "for the past 20 years."Employmentread more
As the Alzheimer's Association International Conference kicks off Saturday in Copenhagen, Denmark, one thing is clear: There is a tremendous public health need for Alzheimer's treatments, but efforts have stalled in the past few years as high-profile programs failed in their late stages.
More than five million Americans have Alzheimer's disease, the sixth-leading cause of death in the U.S. Worldwide, 35.6 million people have either Alzheimer's or dementia, according to the World Health Organization. Those numbers are expected to triple by 2050.
Exactly what causes the disease is unknown, though it's clear that it's associated with a build-up of plaques in the brain.
Researchers at the conference will present data on where things stand against the disease.
"We've made a lot of progress over the past five to 10 years in a couple of areas," Maria Carrillo, the association's vice president of medical and scientific relations, said in a telephone interview Friday from Copenhagen, citing technology for early detection, understanding of risk factors, and—to some extent—therapeutics.
Despite recent setbacks, drugmakers are still working in the space, with 67 medicines currently in development, according to the industry group Pharmaceutical Research and Manufacturers of America, or PhRMA. That's up from 22 in 2004. There are currently five medicines on the market for Alzheimer's, though they only target the symptoms, rather than the underlying cause of the disease, according to the Alzheimer's Association.
Pfizer, Johnson & Johnson, GlaxoSmithKline, Biogen Idec, Roche/Genentech, Eli Lilly and Merck are among companies with the biggest pipeline focus on Alzheimer's. Their efforts mainly aim to clear or prevent plaques called amyloid beta from building up in the brain.
After programs from Lilly and Pfizer, J&J and Elan Pharmaceuticals failed in 2012, efforts have shifted to attempting to treat Alzheimer's earlier in the course of the disease.
Beyond needing a better understanding of the biology, other problems persist in Alzheimer's drug development. Late-stage trials still take five to six years because of difficulty enrolling and the period of time required to observe change in patients, Carrillo said. And while U.S. federal funding for Alzheimer's research got a $122 million boost this year, the National Institutes of Health still allocates about $600 million to the disease, compared with more than $5 billion for cancer, she pointed out.
"We've actually changed the trajectory of life expectancy for cancer, we did the same thing for heart (disease), and certainly did the same thing for HIV," Carrillo said. The spending on Alzheimer's and dementia, she said, "is not commensurate with the disease."
Among the 67 medicines in development, here's where drugmakers stand:
—By CNBC's Meg Tirrell