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Wall Street on edge ahead of key Greece meeting

U.S. stock index futures signaled a lower open on Friday ahead of a crucial meeting between Greece and its euro zone creditors which put investors on edge.

The news comes after Germany rejected Greece's request to extend its loan agreement Thursday, calling it a "Trojan horse" designed to win more concessions on the country's international bailout than it wants to grant.

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Yves Herman | Reuters

Without securing additional funding, Greece is set to run out of money to pay down its debts as early as the end of March, risking default and a possible exit from the euro zone.

On the data front, it should be a low-key end to the week, with just the Markit flash manufacturing PMI due, together with CPI data revisions.

Friday will also be a quiet day for earnings, with just a handful of companies reporting including Deere and Public Service before market open.

Read MoreUS urges Greece, creditors to end impasse

In oil markets, Brent crude slipped below $60 per barrel before ticking back over the key level Friday, as sky-high U.S. crude supply weighed on prices.

U.S. crude inventories rose to 425.6 million barrels last week, up by 7.7 million barrels, data from the Energy Information Administration showed Thursday, marking the sixth straight week of record high gains. U.S. crude traded around $51.17 per barrel.

Back in Europe, markets were lower on Friday, with investors reacting to fresh economic data amid continued uncertainty over Greece.

Pacific Investment Management Co. on Friday said Paul McCulley is stepping down as chief economist and managing director.

Deere said it earned $1.12 per share for its latest quarter, well above the 83 cent consensus estimate, with revenue also beating forecasts. However, the farm machinery manufacturer highlighted difficult global market conditions and said it expected a 17-percent drop in equipment sales for 2015.

Barclays downgraded Wal-Mart to "equal weight" from "overweight," saying the retailer is unlikely to see near-term benefits from its just-announced increase in wages that offset the higher expenses.

Newmont Mining earned an adjusted 17 cents per share for its latest quarter, 7 cents above estimates, with its revenue also beating forecasts. Newmont said its "growth projects" are doing particularly well.

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The Noodles restaurant chain missed estimates by a penny with adjusted quarterly profit of 13 cents per share, with revenue falling just below estimates as well. It also cut its full-year guidance, as same-restaurant sales growth fails to meet prior forecasts.

CNBC's Peter Schacknow contributed to this report.