U.S. stock index futures indicated a lower open on Tuesday amid of a raft of major economic data releases, which investors will look to for signals on the timing of a rate hike.
"Futures are reflecting the move in the overseas data," said Art Hogan, chief market strategist at Wunderlich Securities.
European shares traded mixed, while Chinese shares plummeted after the Reserve Bank of Australia cut interest rates for the second time this year.
In the United States, March trade figures showed that the trade deficit was $51.4 billion, the largest since 2008 as imports surged. February's figure was increased slightly to $35.9 billion from $35.4 billion.
Analysts expected the March trade deficit to widen to $42.5 billion.
In other economic news, April's non-manufacturing ISM comes at 10:00 a.m. ET, and the PMI services index at 9:45 a.m.
The rest of the week includes reports on jobs, with the ADP national employment report; weekly jobless claims and finally the Labor Department's non-farm payrolls report for April on Friday.
Walt Disney delivered quarterly earnings and revenue that topped analysts' expectations on Tuesday.
U.S. crude oil topped $60 a barrel for the first time since Dec. 11, 2014, after protesters shut down a Lybian port and put pressure on exports.
European equities were mixed on Tuesday as investors kept an eye on the ongoing Greece bailout drama and earnings from banking giants HSBC and UBS.
HSBC reported a better-than-expected rise in pre-tax profits for the first quarter of the year, to $7.06 billion, after its investment banking division had a more profitable three months than forecast. Shares slipped over 2 percent in mid-morning trade in London after the results.