U.S. stock index futures turned lower as Wall Street digested the monthly jobs report that missed expectations.
It was a "weak report. I can't find too many good things in it," said David O'Malley, CEO of Penn Mutual Asset Management. "I think this was bad news enough that stocks had to worry about it."
He said investors will see if "this is the sign of something bigger or just a weak report in a generally positive trend."
The Dow futures fell more than 200 points, after earlier rising nearly 100 points, as the stock index futures all gave up early morning gains. The 10-year yield fell below 2 percent for the first time since August. The 2-year yield fell to 0.57 percent.
The euro gained against the dollar to briefly top $1.13 ,with the yen at 119.17 yen against the dollar.
The U.S. economy created 142,000 jobs in September, a number far below the expected 203,000 and could cool expectations that the Federal Reserve will start raising interest rates soon.
Unemployment held at 5.1 percent, according to the Labor Department. The participation rate plunged to 62.4 percent.
Average hourly wages fell by a cent to $25.09 during the month and were up only 2.2 percent from the same month in 2014, pointing to marginal inflationary pressures, Reuters said.
Fed funds futures are now pricing the first rate hike in March 2016.
The Fed has said it will base its decision on economic data, though it did caution that it held off in September because of international developments, meaning a slowing China and its possible impact on the economy.
Factory orders are due at 10:00 a.m.
In Europe, the pan-European Stoxx 600 index turned lower on Friday morning, with investors across the globe also digesting the nonfarm payrolls for September.
In Asia, Japan's Nikkei finished just 0.02 percent higher while Hong Kong's Hang Seng surged 3.17 percent. Markets in mainland China remained closed for the National Day holiday, which lasts one week.
In oil markets, Brent crude traded near $48 a barrel, up half a percent, while U.S. crude pared gains to trade about 0.4 percent higher at $44.89 a barrel as of 8:45 a.m.
Read More Early movers: DNKN, MDLZ, MU, AMD, JWN, TMUS, S, QCOM & more
No significant earnings are expected today.
--CNBC's Patti Domm contributed to this report.