"We respectfully request a two-week continuance of the scheduled conference so that Mr. Shkreli can finalize his engagement of new counsel and we can properly transition the matter to the new attorneys."
The lawyers noted that, "The need to request an adjournment arose over the course of this holiday weekend."
Shkreli's current lawyers did not say in the letter why he wants to replace them.
"No comment," Shkreli wrote in an email when CNBC asked about the situation.
His current lawyers have not responded to a request for comment.
Matsumoto approved the request to a continuance, and set the next hearing for Feb. 3, according to a notification posted on the federal court system's website.
Shkreli achieved widespread notoriety in September after his new company, Turing Pharmaceuticals, raised the price of a decades-old drug known as Daraprim by more than 5,000 percent. Daraprim, which is used to treat a parasitic condition seen in patients with HIV and in pregnant women, went from costing $13.50 per pill to $750 per pill, overnight.