Ahead of the trip, the Iranian government stated on its website that Rouhani's aim was to "develop relations with European Union countries and the trip to Italy and France is aimed at growth and development, as well as job creation for the country."
"This trip is happening during a very important historic point and post-JCPOA (the "joint comprehensive plan of action" commonly known as the Iran deal on its nuclear program) and post-sanctions era and, therefore, it is significantly important," Rouhani told reporters as he left for Europe. The Iranian leader also tweeted that he was looking forward to exploring opportunities in Italy.
Rouhani is expected to address an Iran-Italy business forum on Tuesday and will then meet Pope Francis where human rights issues and ongoing conflict in the Middle East, including Syria, are expected to be discussed. The trip comes as Iran itself tries mend relations with the West after almost economic sanctions on the country were expanded in 2006 for its alleged building of nuclear weapons.
That isolation came to an end after trade restrictions were lifted earlier in January after Iran was deemed to have complied with international obligations to curb its nuclear program. Iran has certainly wasted no time in signing deals in an attempt to get its economy back on a global stage.
On Sunday, Reuters reported that Iran planned to buy 114 aircraft from European plane maker Airbus as soon as March The republic could need as many as 500 new planes over the next three years, lawmaker Mahdi Hashemi, the chairman of the parliament's Development Commission, said.
Read MoreIran's stock market roars as sanctions go away
More announcements could be announced on Wednesday as Rouhani heads to Paris. He is expected to be received at the Elysee Palace on Thursday but there will be no state dinner for Rouhani and his ministers after France refused an Iranian request for no wine to be served at such an event. Italy was reportedly far more compliant by agreeing to the request from the strict Islamic Republic.
There was some scepticism from analysts over the trade deals. Wolfango Piccoli, co-president of Teneo Intelligence, said the deals should be scrutinized.
"Trailing along with him will be an entourage of businesspeople, bankers and ministers. It will be important to ignore the numbers that will be bandied around concerning the various accords that are being signed and instead pick through any more concrete trade agreements and deals as this will be the area in which the first real commercial exchanges will take place," Piccoli said in a note on Monday.
"Investment agreements will take far longer to negotiate and much of the information that is released about such putative deals this week will be largely hyperbole."
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