Schaeuble has never been backwards in coming forwards in terms of his criticism of other countries' organizations' policies, but the comments are not likely to sit well with ECB President Mario Draghi. Schaeuble is not the only German to criticize the bank's direction either, with one of the bank's own governing council members consistently critical of its loose monetary policy.
Bundesbank President Jens Weidmann said that last month's ECB stimulus measures went too far, according to comments published by Dow Jones. "All things considered, the decisions for me went too far and the comprehensive package of measures didn't convince me," Weidmann said.
However, it was Weidmann that defended the ECB from criticism from German policymakers, such as Schaeuble, earlier this month, both asserting the ECB's independence and rebuking politicians for attempting to put pressure on Mario Draghi to change the ECB's strategy.
"It's not unusual for politicians to have opinions on monetary policy, but we are independent," Weidmann told the Financial Times earlier in April.
"The ECB has to deliver on its price stability mandate and thus an expansionary monetary policy stance is appropriate at this juncture regardless of different views about specific measures."
The staunch defense of the ECB has raised suspicions that Weidmann could be angling for the top job at the central bank although Draghi's term has a long time to run, expiring in 2019, and a German running a German-based institution could prompt more questions over the bank's independence and impartiality.
Follow CNBC International on Twitter and Facebook.