In the past, France and Spain have both put forward proposals for a new class of "virtual" permanent establishment, which would make it possible to tax companies such as Google even if when they do not do business through a physical presence in the country.
Google said in a statement: "We comply with the tax law in France, as in every other country in which we operate. We are co-operating fully with the authorities in Paris to answer their questions, as always."
Antoine Colonna d'Istria, a lawyer and authority on French tax issues, said that using such a big number of data experts was unusual.
"They have clearly entered a second stage of the investigation, trying to gather information that they have not been able to get hold of in a normal inquiry," he said.
Mr Colonna d'Istria added that under French law, the investigators had 24 hours to search for information on the premises, including accessing servers on the network but not necessarily in France.
In February, Michel Sapin, France's finance minister, said the amount that Google would have to hand over to the government would be "way bigger" than the UK settlement.
The European Commission is also pursuing an investigation into whether some EU governments used illegal state aid when giving tax breaks to large multinational companies, including Apple, Amazon and McDonald's.
Google's tax arrangements are not the subject of a full probe by Brussels, but Margrethe Vestager, the competition commissioner, is studying a complaint from the Scottish National party in relation to Google's fiscal arrangements with UK authorities.
The raid on Google's Paris offices comes just days after the US company appealed against a demand by French regulators to apply the EU's "right to be forgotten" ruling outside Europe.
CNIL, France's data protection agency, called on the company to remove search results deleted under the controversial clause from all its websites, even if they are based outside the EU.
The company currently removes search results from European domains, such as .fr in France or .co.uk in Britain. Earlier this year, it also started removing results from all international domains, such as .com, if they are accessed from the applicant's country.
But CNIL wanted Google to scrub results from all versions of its website worldwide. The regulator issued the company with a €100,000 fine this year for failing to do so.
Additional reporting by Christian Oliver