One of the STOXX 600's best performer was Roche, which closed up 4 percent following the announcement of positive results in its trials of drug Gazyva.
One of the worst performers was Banco Popular, which ended down over 8 percent after announcing a rights issue on Thursday.
Investors kept a close eye on the first day of trading of the Philips Lighting spin-off on Friday. Philips set pricing in the initial public offering (IPO) of its lighting arm at 20 euros per share and the Amsterdam-listed shares of the company rose to trade at 21.6 euros per share. Philips rose following the IPO, closing up 1.2 percent.
PostNL and Bpost shares were suspended during trade, following reports of a possible merger between the mail operators. In morning trade, PostNL had jumped over 5 percent.
Autos under-performed as a sector, with Renault, Peugeot Citroen and Fiat shares all closing sharply lower, after Credit Suisse cut its price target on each of the stocks.