Despite the fallout in bank stocks, which have hit British concerns particularly hard on worries about disruptions in investments, Lew said European banks are "better equipped" to deal with a Brexit than they would have been in 2008.
In prepared remarks for his Monday address of the annual meeting of the Bretton Woods Committee, Lew said: "We respect the decision of the voters in the U.K. and will work closely with London, Brussels and our international partners to ensure continued economic stability, security and prosperity in Europe and globally." The Bretton Woods Committee consists of top leaders in business, finance, academia and nonprofit organizations.
"As we move forward, it is important to stress that U.K., European and global policymakers have the tools necessary to support not just financial stability — but also to promote economic growth," Lew said in his speech.
In the wake of the unexpected U.K. vote, the U.S. is reminded again of the importance of its leadership in the global economy, he said.
"Sustaining that leadership, and adapting it to the challenges of our time, remain indispensable to the well-being of American workers and families, as well as to the ability of the United States to project its values and achieve its larger foreign policy objectives," he said.