"We could do with a bit of meanness in American society," said Yiannopoulos, who writes for Breitbart.com and is a former self-proclaimed Twitter "super villain." "This cult of being nice all the time and not saying what we really think, not saying what's actually happening. ... It results in horrible things happening."
Yiannopoulos is no stranger to controversy: He has argued that provocative social media personalities, or trolls, will save the world, calling out crime and dangers that others are scared to address. His critics on both sides of the aisle, however, have called him a "monster" and a "bully."
"The press seems determined to label the 'alt-right' as a misogynist, hateful, racist, homophobic, anti-Semitic movement," Yiannopoulos said. "Yet at the same time tries to crown a gay Jew — who never shuts up about his black boyfriends — as the leader of it," he said, referring to himself.
Yiannopoulos said that a candidate like Trump, who also touts his honesty, has tapped into a larger trend in society widely called the "alt-right."
"People are getting a little sick, on all sides of the political divide, of the nannying, safe-space culture from the left," Yiannopoulos said. "Of the language policing: 'Everything is racist, everything is homophobic.' That kind of chilling effect, on culture, on freedom of expression, even on journalism, has started to become very obvious, and I don't think voters like it."
Yiannopoulos' much-followed Twitter account, @nero, was suspended after he allegedly violated its harassment policy. The reaction to his jabs — some at stars like Leslie Jones — was said by some to mark a change in Twitter's business strategy, as it struggled to strike a balance between protecting free speech and curbing abuse.
It comes amid rumors that Twitter might be open to selling itself — spurred after co-founder Ev Williams said on Bloomberg TV that the company must "consider the right options" for the company's ownership.
In light of his own beef with Twitter, Yiannopoulos said he's skeptical the social media company would find a buyer if it did consider a sale. He said, contrary to conventional commentary, he thinks the crackdown on abuse has led to Twitter's downfall.
"[Co-founder and CEO] Jack Dorsey's very clearly checked out of this business," Yiannopoulos said. "He doesn't care. He's not interested. The business is tanking. They're losing their users."
Twitter declined to comment to CNBC on Yiannopoulos' remarks. The Trump campaign did not immediately respond to a request for comment.