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After years of insisting otherwise, the GOP nominee acknowledged on Friday that the president was, in fact, born in the United States. Clinton said, however, that his admission was a "disgrace" as he expressed "zero regret."
The Democratic presidential nominee said Trump has tried to "deflect blame" and compared his behavior to that of a child.
Clinton tweeted that Trump cannot undo years of trying to undermine Obama, the first African-American president of the United States.
In Quinnipiac University's most recent poll, Clinton beats Trump by 47 points among nonwhite voters.
Clinton emphasized that Trump's role in broadcasting his birtherism is "what turned Trump from an ordinary reality TV star into a political figure."
Clinton concluded her tweet storm by calling on Trump to apologize to Obama and the American people.
Trump's campaign did not immediately respond to requests for comment.
— CNBC's Jacob Pramuk contributed to this report.