The Fed chair will speak before the Committee on Financial Services at 10 a.m. ET about banking supervision and regulation. Five other Fed officials will make public appearances on Wednesday, namely, Minneapolis Fed President Neel Kashkari, St. Louis Fed President James Bullard, Chicago Fed President Charles Evans, Cleveland Fed President Loretta Mester and Kansas City Fed President Esther George.
Meanwhile, U.S. economic data released on Wednesday included monthly durable goods orders, which came in unchanged. The Mortgage Bankers Association also reported weekly mortgage applications fell by 0.7 percent. Weekly oil inventories data are due at 10:30 a.m. ET.
Blackberry shares rose more than 3 percent before the bell after posting quarterly results.
The dollar index, which measures the greenback against a basket of currencies, continued to gain on Wednesday, trading around 95.46 at 8:24 a.m. ET. This was higher than its last close of 95.44 but still down from September's peaks above 96.00.
Oil prices rose slightly on Wednesday, having slipped around 3 percent on Tuesday after hopes waned that Saudi Arabia and Iran would reach a deal to tackle the global crude supply glut on the sidelines of an energy conference in Algiers.
U.S. stock indexes closed higher on Tuesday, boosted by the perceived stronger performance from Democratic candidate Hillary Clinton than Republican Donald Trump in the first U.S. presidential debate. A better-than-expected reading for U.S. consumer confidence also supported sentiment.
Tuesday's Wall Street close
Stocks to watch on Wednesday include Nike, which fell over 2 percent in extended hours' trade after reporting disappointing earnings, which predicated a wave of analyst downgrades.
Also worth an eye is Facebook, after it said it would appeal an order by a German regulator to stop storing data of German users of its messaging app WhatsApp and erase all previously collected information.