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The move was "so sad," said Michael Reagan, son of Ronald Reagan and president of The Reagan Legacy Foundation.
He also said his "father would be so embarrassed" by the current situation.
Trump tweeted that his "team of deploarables" would be running his account during the event.
Clinton said in a Facebook post that she has "no intentions of allowing [Trump] to hijack this debate, this election, or this country with his divisive rhetoric about people or groups of people he doesn't like."
American businessman, Mark Cuban tweeted "Sniffle distance is important."
The author of Harry Potter, J.K. Rowling tweeted about Trump's accusations "just words, folks."
Political consultant Frank Luntz tweeted about reaction to the lack of the handshake.
Donald Trump's oldest son tweeted from the town hall about Hillary Clinton's emails.
Hawaii Senator Brian Schatz compared the debate to Saturday Night Live.
Atul Gawande, surgeon and writer, tweeted on Donald Trump's health policy.
Green Party presidential candidate Jill Stein joined the debate through Facebook Live.
Former U.S. Ambassador to Russia Michael McFaul tweeted "Trump just refuted Clapper."
Donald Trump's team released this chart during the debate on Twitter.
California Senator Barbara Boxer compared Donald Trump's behavior with the moderators to a sinking ship.
In response to the a question from social media about Syria and Russia, Senator and Democratic Vice Presidential nominee Tim Kaine tweeted "Get real."
After referring to the city of Aleppo numerous time, Merriam-Webster dictionary tweeted that is it "Aleppo."
The Republican Vice Presidential Mike Pence nominee tweeted after the debate.
The last question was for both presidential candidates to say what they respected about each other. Massachusetts Senator Elizabeth Warren tweeted that she agreed with Donald Trump's answer.