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Looking like a Clinton win in Electoral College analysis, political analyst says

All signs are pointing to a Hillary Clinton win in November, political analyst Larry Sabato said Monday.

In his latest analysis of the Electoral College map, Sabato said the Democratic nominee is back up to 341 electoral votes and Republican nominee Donald Trump is below 200. The winner needs 270 electoral votes.

Part of Trump's decline is due to the leaked 2005 video that shows Trump joking about groping women without their consent, the director of the Center for Politics, University of Virginia told CNBC's "Power Lunch."

"That's probably as good as it's going to get for Hillary Clinton and as bad as it's going to get for Donald Trump."

While it's possible the vote will get somewhat tighter as Election Day nears, Sabato doesn't think it will be enough for Trump to pull off a win.

"I just can't imagine it getting so tight that it's unpredictable or Trump going ahead. There's just too much water under the bridge for Trump," he said. "The baggage that he's carrying … could now fill a 747."

In fact, Ohio has now gone from "leans Republican" to "leans Democratic," and without Ohio, there is "absolutely zero" chance for Trump to get the electoral votes needed, Sabato noted.

Clinton is leading Trump 52 percent to 38 percent in a two-way race, according to the latest NBC News/ Wall Street Journalpoll released Monday. In a four-way race, which includes Green Party candidate Jill Stein and Libertarian Party candidate Gary Johnson, Clinton leads Trump 46 percent to 35 percent.

— CNBC's John Harwood contributed to this report.