On the individual stock front, Ericsson was the biggest drag on the STOXX 600, slumping 20.2 percent after the company issued a profit warning.
The news pushed other tech stocks down, including Nokia which fell 5.1 percent and AMS which slipped 3 percent. Overall, the tech sector closed down 2.86 percent.
On the opposite end, Lufthansa jumped over 4 percent after Kepler Cheuvreux raised its price target for the stock. Aegon was one of the best performers, up 4.56 percent, after Macquarie started with an outperform rating on the stock.
Pagegroup jumped over 3 percent after Kepler Cheuvreux, JP Morgan, HSBC and Barclays raised their price target on the recruitment firm.
Shares of jewelry manufacturer Pandora popped 2.64 percent, after the Dutch firm launched itself online in China on the Alibaba Group's platform Tmall.com.
Despite saying it expected to open more stores in 2016 and that like-for-like sales were up in particular regions during its third quarter, U.K. listed firm Domino's Pizza fell over 5 percent in European trade.