The quakes, which struck about two hours apart, caused the collapse of several old structures, including a number of historic rural churches that were empty at the time.
The second quake was measured at 6.0 magnitude by the U.S. Geological Survey and the first measured 5.4.
More than three hours after the first quake, Civil Protection department chief Fabrizio Curcio said only one person was slightly injured.
All indications were that the damage would not approach that caused by the major quake that struck the Marche, Lazio and Umbria regions on Aug. 24, which devastated several towns and killed nearly 300 people.
Amateur video footage on television showed clouds of dust rising as parts of buildings collapsed in some towns, including Camerino in the Marche region, where a bell tower fell on a building.
Massive boulders, some the size of cars, fell on the main north-south road of the Nera River valley that links mountain communities.